業績(1984〜1999年)

著書

1)Role of oxygen in lipid peroxide of skin exposed to ultraviolet light.
Ogura,R.,Sugiyama,M.,Sakanashi,T.,Hidaka,T.
The Biological Role Reactive Oxygen Species in Skin(eds.By Hayaishi,O.,Imamura ,S.,Miyachi,Y.),Univ. Tokyo Press,55-63,1987

2) Biochemical aspects of nucleosides in normal and hyperkeratotic epidermis :nucleoside phosphate kinase and DNA polymerase.
Ogura,R.,Sugiyama,M.
Processes in Cut-aneous Epidermal Differentiation(eds. By Bernstein,I.A.,Hirone,T.)Praeger Publ., 11-29,1987

3)Cellular membrane damage and lipid peroxide following exposure of the skin to ultraviolet rays.
Ogura,R.,Sugiyama,M.
Cutaneous Agings (eds.By Kligman,A.M.,Takase,Y.) Univ. Tokyo Press, 459-471,1988

4)ESR study on membrane fluidity of B-16 melanoma cells exposed to ultraviolet light.
Ogura,R.,Sugiyama,M.,Hidaka,T.
Medical,Biochemical and Chemical Aspects of Free Radicals(eds.by Hayaishi,O.,Niki,E.,Yochikawa,T.),Elsevier Science Publ.,865-868,1989

5)Reactive oxidants in skin:UV-induced lipid peroxidation.
Ogura,R.,Sugiyama,M.
Oxidative Stress in Dermatology(eds.By Fuchs,J.,Packer,T.)Mercel Decker, 49-63,1993

6)生体関連クロムのESR.杉山 正康,バイオサイエンスESR[2](桜井弘編),廣川書店323-340,1996


総説

1)表皮のフリーラジカル.
小倉良平,杉山正康,三嶋祐次,熊野修治
西日本皮膚,46:1093-1099,1984

2)重金属と活性酸素(フリーラジカル).
杉山正康,
組織培養,17:47-50.1991

3)紫外線と活性酸素・フリーラジカル.
小倉良平,杉山正康. 
活性酸素・フリーラジカル,3:270-277.1992

4)Role of physiolgical antioxidants in chromium(VI)-induced cellular injury.
Sugiyama,M.
Free Radical Biology & Medicine,12:397-407,1992

5)6価クロムによる細胞損傷発現に及ぼすビタミン類の効果.
杉山正康 
ビタミン,66:695-703.1992

6)Role of cellular antioxidants in metal-induced damages.
Sugiyama,M.
Cell Biology and Toxicology,10:1-12,1994


学術論文(国際論文)

1)Lipid peroxidation and radical formation in methyl linoleate following ultaviolet light exposure.
Sugiyama,M.,Kajiyama,K.,Hidaka,T.,Ogura,R.
Journal of Dermatology,11:455-459,1984

2)Preferential DNA-protein cross-linking by NiCl2 in magnesium-insoluble regions of fractionated Chinese hamster ovary cell chromatin.
Patierno,S.R.,Sugiyama,M.,Basilion,J.P.,Costa,M.
Cancer Research,45:5787-5794,1985

3)Differences in the effects of Hg(II) on DNA repair induced in Chinese hamster ovary cell by ultaviolet or X-rays.
Christie,N.T.,Cantoni,O.,Sugiyama,M.,Cattabeni,F.,Costa,M
Molecular Pharmacology,29:173-178,1986

4)Delayed alteration of membrane fluidity in intact culutured B-16 melanoma cells affected by ultaviolet irradiation.
Sakanashi,T.,Sugiyama,M.,Suematsu,T., ,Hidaka,T.,Ogura,R.
Biotechnology and Applied Biochemistory,12:341-346,1986

5)Membrane fluidity in Ehrlich ascites tumor cells treated with adriamycin.
Sugiyama M.,Sakanashi T.,Okamoto K.,Chinami M.,Hidaka T.,Ogura R.
Biotechnology and Applied Biochemistry,8:217-221,1986

6)Decreased membrane fluidity of  erythrocytes from a patient with hemolytic uremic syndrome.
Hidaka,t.,Sugiyama,M.,Sakanashi,T.,Furuno,H.,Matsuura,R.,Ogura,R.
Acta Paediatrica Japonica,28:797-802,1986

7)Characterization of DNA lesions induced by CaCrO4 in synchronous and asynchronous cultured mammalian cells.
Sugiyama,M., Patierno,S.R.,Cantoni,O., Costa,M.
Molecular Pharmacology,29:606-613,1986

8)Comparison DNA lesions and cytotoxicity induced by calcium chromate in human,mouse and hamster cell lines.
Sugiyama,M.,Wang,X-W., Costa,M.
Cancer Research,46:4547-4551,1986

9)Effct of Ni(II) on DNA-protein binding,thymidine incorporation,and sedimentation pattern of chromatin fractions from intact mammalian cells.
Patierno,S.R.,Sugiyama,M., Costa,M.
Journal of Biochemical Toxicology,2:13-23,1987

10)Effect of vitamin E,vitamin B2  and selenite on DNA single strand breaks induced by sodiumu chromate(VI).
Sugiyama,M.,Ando,A.,Furuno,H.,Furlong,N.B.,Hidaka,T.,Ogura,R.
Cancer Letter,38:1-7,1987

11)Increased platelet thromboxane synthesis in renal glomerular diseases.
Nakano,M.,Hidaka,T.,Ogura,R.,Ueta,H.,  Sugiyama.M
Prostaglandins Leukotrienes and Essential Fatty Acids,31:113-116,1988

12)Changes of membrane fluidity and Na,K-ATPase activity during cellular differentiation in the guinea pig epidermis.
Tanaka,T.,Ogura,R.,Hidaka,T.,Sugiyama,M.
Archives of Dermatological Research,280:29-32,1988

13)Stimulation polyadenosine diphosphoribose synthesis by DNA lesions induced by sodium chromate in Chinese hamster V-79 cells.
Sugiyama,M.,Costa,A.,Nakagawa,T.,Hidaka,T.,Ogura,R.
Cancer Research,48:1100-1104,1988

14)Fatty acid composition of platelet phospholipids and plasma total lipids in Kawasaki disease.
Hidaka,T.,Furuno,H.,Sugiyama,M.,Kagiyama,,A.,Ogura,R.,Yamashita,F.,Kato,H.,Inokuchi,T.
Acta Paediatrica Japonica,30:294-298,1988

15)Membrane responses of B-16 melanoma cells to single exposure to ultraviolet light.
Ogura,R.,Sugiyama,M.,sakanashi,T.,Suematsu,T.,Hidaka,T.,Morikawa,F.,Kon,Y.
Archives of Dermatological Research,280:481-486,1989

16)Effect of UV-B irradiation on release of arachidonic acid acid from B-16 melanoma cells.
Suematsu,T.,Hidaka,T.,Sakanashi,T.,Sugiyama,M.,Ogura,R.
Prostaglandins Leukotrienes and Essential Fatty Acids,35:153-156,1989

17)Effect of vitamin E on survival,gultathione reductase and formation of chromium(V) in Chinese hamster V-79 cells treated with sodium chromate(VI).
Sugiyama,M.,Ando,A.,Ogura,R.
Carcinogenesis,10:737-741,1989

18)Effect of vitamin E and vitamin B2  on chromate-induced DNA lesions.
Sugiyama,M.
Biological Trace Element Research,21:399-404,1989

19)Vitamin B2 –enhancement of sodium chromate(VI)-induced DNA single strand breaks:ESR study of the action of vitamin B2.
Sugiyama,M.,Ando,A.,Ogura,R.
Biochemical and Biophysical Reseach Communications,159:1080-1085,1989

20)Influence of vitamin B2 on formation of  chromium(V),alkalie-labile sites, and lethality of sodium chromate(VI) in Chinese hamster V-79 cells.
Sugiyama,M.,Ando,A.,Nakao,K.,Ueta,H.,Hidaka,T.,Ogura,R.
Cancer Research,49:6180-6184,1989

21)Stimulation of prostaglandin synthesis by cholecystokinin in primary culture cells bovine gallbladder muscle.
Hidaka,T.,Nakano,M.,Shingu,M.,Sugiyama,M.,Inokuchi,T.,Ogura,R.
Prostaglandins Leukotrienes and Essential Fatty Acids,38:113-117,1989

22)Changes electoron spin resonance membrane fluidity in hexadecane-induced hyperproliferative epidermis.
Tanaka,T.,Ogura,R.,Hidaka,T.,Sugiyama,M.
Journal of Investigative Dermatology,93:682-686,1989

23)Detection of mitochondrial membrane changes in myocardial ischemia with ESR spin labeling technique.
Shin,G.,Sugiyama,M.,Shoji,T.,Kagiyama,A.,Sato,H.,Ogura,R.
Journal of Molecular and Cellular Cardiology,21:1029-1036,1989

24)Distribution of  superoxide disumutase activity in the epidermis:measurement with electoron spin resonance spin trapping .
Ogura,R.,Ueta,H.,Sugiyama,M.,Hidaka,T.
Journal of Investigative Dermatology,94:227-229,1990

25)02- spin trapping on cardiac submitochondrial particles isolated from ischemic and non-ischemic myocardium.
Ueta,H.,Ogura,R.,Sugiyama,M.,Kagiyama,A.,Shin,G.
Journal of Molecular and Cellular Cardiology,22:893-899,1990

26)Protective effect of vitamin E against chromosomal aberrations and mutation induced by sodium chromate in Chinese hamster V-79 cells.
Sugiyama,M.,Lin,X.,Costa,M.
Mutation Research,260:19-23,1991

27)Diffrences in the effect of vitamin E on nickel sulfide or nickel chloride-induced chromosomal aberrations in mammalian cells.
Lin,X.,Sugiyama,M.,Costa,M.
Mutation Research,260:159-164,1991

28)Effect of ascorbic acid on DNAamage,  cytotoxicity, gultathione reductase , and formation of paramagnetic chromium in Chinese hamster V-79 cells treated with sodium chromate(VI).
Sugiyama,M., Tuzuki,K.,Ogura,R.
Journal of Biological Chemistry,266:3383-3386,1991

29)Reduction of chromium(VI) in Chinese hamster V-79 cells.
Sugiyama,M.,Tuzuki,K.,Hidaka,T.,Ogura,R.,Yamamoto,M.
Biological Trace Element Research,30:1-8,1991

30)Non-dimer DNA damage in Chinese hamster V-79 cells exposed to ultraviolet-B light.
Matsumoto,K.,Sugiyama,M.,Ogura,R.
Photochemistry and Photobiology,54:389-392,1991

31)Electoron spin resonance studies on the mechanism of adriamycin-induced heart mitochondrial damages.
Ogura,R.,Sugiyama,M.,Haramaki,N.,Hidaka,T.
Cancer Research,51:3555-3558,1991

32)Involvement of active oxygen in lipid peroxide radical reaction of epidermal homogenate following ultraviolet light exposure.
Nishi,J.,Ogura,R.,Sugiyama,M.,Hidaka,T.,Kohno,M.
Journal of Investigative Dermatology,97:115-119,1991

33)Effect of vitamins on chromate-induced damages.
Sugiyama,M.
Environmental Health Perspective,92:63-70,1991

34)Generation of  leukotrienes and hydroxyeicosatetraenoic acids in peritoneal macrophages of tumor-bearing mice.
Hidaka,T.,Tsuruta,M.,Tomita,Y.,Inokuchi,T.,Sugiyama,M.,Ogura,R.
Prostaglandins Leukotrienes and Essential Fatty Acids,44:185-190,1991

35)Prevention of 4-pentenoic acid-induced liver injury in rats by 16,16-dimethyl PGE2.
Hidaka,T.,Inokuchi,T.,Nakamura,Y.,Kotegawa,M.,Sugiyama,M.,Ogura,R.
Experimental and Molecular Pathology,55:135-142,1991

36)Mechanism of lipid radical formation following exposure of epidermal homogenate to ultraviolet light.
Ogura,R.,Sugiyama,M.,Nishi,J.,Haramaki,N.
Journal of Investigative Dermatology,97:1044-1047,1991

37)Riboflavin deficiency caused by treatment with adriamycin.
Ogura,R.,Ueta,H.,Hino,U.,Hidaka,T.,Sugiyama,M.
Journal of  Nutritional Science and Vitaminology,37:473-477,1991

38)Effect of vitamin E on cytotoxicity, DNA single strand breaks, chromosomal aberrations, and mutation in in Chinese
hamster V-79 cells exposed to ultraviolet-B light.
Sugiyama,M.,Tsuzuki,K.,Matsumoto,K.,Ogura,R.
Photochemistry and Photobiology,56:31-34,1992

39)Potenciation of sodium chromate(VI)-induced chromosomal aberrations and mutation by vitamin B2 in Chinese hamster V-79 cells .
Sugiyama,M.,Tuzuki,K.,Lin,X.,Costa,M.
Mutation Research,283:211-214,1992

40)DNA single strand breaks and cytotoxicity induced by sodium chromate(VI) in hydrogen peroxide-resistant cells.
Sugiyama,M.,Tsuzuki,K.,Haramaki,N.
Mutation Research,299:95-102,1993

41)Influence of o-phenanthroline on DNA single strand breaks, alkali-labile sites, gultathione reductase, and formation of chromiu(V), in in Chinese hamster V-79 cells treated with sodium chromate(VI).
Sugiyama,M.,Tsuzuki,K.,Haramaki,N.
Archives of Biochemistry and Biophysics,305:261-266,1993

42)Effect of α-tocopherol on high energy phosphate metabolite levels in rat heart by 31P NMR using a Langendorff perfusion technique.
Kotegawa,M.,Sugiyama,M.,Shoji,T.,Haramaki,N.,Ogura,R.
Journal of Molecular and cellular Cardiology,25:1067-1075,1993

43)Effect of glutathione depletion on the formation of pramagnetic chromium in Chinese hamster V-79 cells.
Sugiyama,M.,Tsuzuki,K.
FEBS Letters,341:273-276,1994

44)Role of paramagnetic chromium in chromium(VI)-induced damage in cultured mammalian cells.
Sugiyama,M.
Environmental Health Perspective,102:31-33,1994

45) DNA single- strand breaks and cytotoxicity induced by chromate(VI), cadomium(II), and mercury(II) in hydrogen peroxide-resistant cell lines.
Tsuzuki,K.,Sugiyama,M.,Haramaki,N.,Kotegawa,M.
Environmental Health Perspective,102:341-342,1994

46)Involvement of activated polymorphonuclear leukocytes in galactosamine-induced hepatic injury in rats.
Hino,U.,Kumashiro,R.,Tanaka,M.,Shimada,M.,Sata,M.,Sugiyama,M.,haramaki,N.,Tanikawa,K.
Journal of Clinical Biochemistry and Nutrition,16:27-36,1994

47)Comparison of hepatotoxicity caused by mono- ,di- and tributyltin compounds in mice.
Ueno,S.,Susa,N.,Furukawa,Y.,Sugiyama,M.
Archives of Toxicology,69:30-34,1994

48)Effect of dimethylthiourea on chromium(VI)-induced DNA single- strand breaks in Chinese hamster V-79 cells.
Ueno,S., Sugiyama,M.,Susa,N.,Furukawa,Y.
Mutation Research,346:247-253,1995

49)Formation of paramagnetic chromium in liver of mice treated with chromate(VI).
Ueno,S.,Susa,N.,Furukawa,Y.,Sugiyama,M.
Toxicology and Applied Pharmacology,135:165-171,1995

50)Role of cytochrome P450 in hepatotoxicity induced by di- and tributyltin compound in mice.
Ueno,S.,Susa,N.,Furukawa,Y.,Sugiyama,M.
Archives of Toxicology,69:655-658,1995

51)Protective effect of vitamin E on chromium(VI)-induced cytotoxicity and lipid peroxidation in primary culture of rat hepatocytes.
Susa,N.,Ueno,S., Furukawa,Y.,Sugiyama,M.
Archives of Toxicology,71:20-24,1996

52)Effect of SKF-525A on liver metabolism and hepatotoxicity of tri- and dibutyltin compounds in mice.
Ueno,S.,Suzuki,T.,Susa,N.,Furukawa,Y.,Sugiyama,M.
Archives of Toxicology,71:513-518,1997

53) Protective effect of deferoxamine on chromium(VI)-induced DNA single- strand breaks, cytotoxicity and lipid peroxidation in primary culture of rat hepatocytes.
Susa,N.,Ueno,S., Furukawa,Y.,Sugiyama,M.
Archives of Toxicology,71:345-340,1997

54)Potent protective effect of melatonin on chromium(VI)-induced DNA single- strand breaks, cytotoxicity and lipid peroxidation in primary culture of rat hepatocytes
Susa,N.,Ueno,S., Furukawa,Y.,Sugiyama,M.
Toxicology and Applied Pharmacology,144:377-378,1997


国内論文

1) 表皮中の遊離基(free radical)に対する紫外線の影響。
小倉良平、三嶋祐治、梶山公則、杉山正康、河野雅弘。
久留米医学会雑誌、44:636−640、1981

2) Effect of adriamycin on lipid peroxide,glutathione peroxidase and respiratory responses of mitochondria from the heart,liver and kidney.
Yoon,S.,Kajiyama.K.,Hino,Y.,Sugiyama,M.,Ogura,R.
Kurume Medical Journal,30;1-4,1983

3) 電子スピン共鳴法による表皮の過酸化ラジカルの測定と解析。
杉山正康。
麻酔と蘇生、4:89−92、1983

4) 紫外線照射による表皮の過酸化脂質に対するsuperoxide dismutase クリームの塗布効果。
杉山正康、三嶋祐治、日野雄二、村方祥治、小倉良平。
久留米医学会雑誌、47:233−237、1984

5) 紫外線照射による表皮の過酸化脂質とラジカルの変遷。
杉山正康、金子憲章、鍵山明弘、村方祥治、小倉良平。
久留米医学会雑誌、47:346−350、1984

6) ESRスピンラベル法による細胞膜流動性の測定について-B16メラノーマ培養細胞-。
杉山正康、坂梨俊彦、末松知真、杉山正康、三嶋祐治、日野雄二、村方祥治、小倉良平。
久留米医学会雑誌、47:1301−1308、1984

7)B-16メラノーマ細胞膜流動性に及ぼす紫外線照射の影響。
杉山正康、秋保暁、日高敏博、小倉良平。
日本皮膚科学会雑誌、95、1043−1047,1985

8) Effect of ultraviolet irradiation on cultured B-16 melanoma cells-Membrane fluidity, lipid composition and phospholipase activity-.
Sakanashi,T.,Sugiyama,M.,Suematsu,T.,Ogura,R.
Kurume Medical Journal,32;61-68,1986

9) 赤血球膜流動性低下を伴う溶血性尿毒症症候群。
日高敏博、杉山正康、坂梨俊彦、古野浩秋、小倉良平、進藤静生、松浦伸郎、山本正士。
小児科診療、49:201−205、1986

10)生体膜流動性のESRスピンラベル法による測定-再現性のあるデータを得るには-
坂梨俊彦、中川鉄朗、杉山正康、田中裕穂、末松知真、日高敏博、杉山正康、小倉良平、因正信。
久留米医学会雑誌、49:494−501、1986

11)Alkaline elution 法によるDNA障害の検討について-6価クロムCaCrO4のDNA障害。
杉山正康、小倉良平、Max Costa
久留米医学会雑誌、49:760−764、1986

12)Adriamycin脂質過酸化におけるglucoseおよび3価鉄の影響。
中川鉄朗、坂梨俊彦、杉山正康、古野浩秋、日高敏博、小倉良平。
久留米医学会雑誌、50:163−168、1987

13)小児糸球体腎炎での血小板内アラキドン酸代謝。
日高敏博、中野光朗、古野浩秋、上田浩、杉山正康、小倉良平、山下文雄、進藤静生。
小児科診療、50:1853−1860、1987

14)Assay for lipid peroxide content in mitochondria by thiobarbituric acid reaction.
Ogura,R.,Sakanashi,T.,Nagata,O.,Sugiyama,M.,Kajiyama,K.,Nakagawa,T.,Shin,G.Hidaka,T.
Kurume Medical Journal,34;53-58,1987

15)Electron spin resonance studies on spin label of rat cardiac mitochondoria treated with adriamycin.
Kajiyama,K., Sugiyama,M., Iwahashi,H., Hidaka,T., Entman,M.L.,Shimada,I.,Ogura,R.,
Kurume Medical Journal,50;59-64,1987

16)重金属クロムによるDNA障害について。
杉山正康
久留米医学会雑誌、50:737−750、1987

17)虚血時における心筋ミトコンドリアの膜障害
申呟浩、鍵山明弘、中川鉄朗、古野浩秋、上田浩、杉山正康、日高敏博、小倉良平。
久留米医学会雑誌、50:635−640、1987

18)クロム化合物による過酸化脂質生成について
李志祥、杉山正康、中尾久美、松本卓郎、小倉良平。
久留米医学会雑誌、51:677−681、1988

19)電子スピン共鳴(ESR)スピントラッピング法によるsuperoxide anion(O2-)定量法。
上田浩、杉山正康、鍵山明弘、申呟浩、小路高史、三森史朗、小倉良平、河野雅弘。
久留米医学会雑誌、51:1032−1038、1988

20)UVexposure alters the membrane lipid composition and cell membrane fluidity of intact cultured B-16 melanoma.
Sakanashi,T., Sugiyama,M.,Suematsu,T.,Nakagawa,T.,Hidaka,T., Ogura,R.,
Kurume Medical Journal,35;159-169,1988

21)ESR spin-labeling method of determining fluidity in biological materials(Tissue culture, cardiac mitochondria,erythrocyte and epidermal cells.
Ogura,R., Sugiyama,M.,Sakanashi,T.,Ninomiya,T.
Kurume Medical Journal,35;171-182,1988

22)クロム並びに紫外線毒性に対するTocopheryl succinate 及びRiboflavinの効果。
中尾久美、杉山正康、安藤昭和、小路高史、二宮健、小倉良平。
ビタミン、63:141−145、1989

23)Alkaline elution 法における蛍光DNA定量について。
安藤昭和、杉山正康、中尾久美、松本卓郎、小倉良平。
久留米医学会雑誌、52:249−254、1989

24)心筋ミトコンドリアからのヒドロキシラジカルの検出(スピントラッピング法)。
腹巻信也、三森史朗、小手川雅彦、西寿一、都築克幸、杉山正康、小倉良平。
久留米医学会雑誌、54:210−216、1991

25)湿潤した皮膚では光障害が増強される-ESR spin trapping 法によるhydroxyl radicalの検出-
日本皮膚科学会雑誌、101、1285−1289,1991

26)Arachidonate metabolism in bovine gallbladder mucosa.
Hidaka,T.,Nakano,M.,Inokuchi,T.,Sugiyama,M.,Nishi,J.,Ogura,R.
Kurume Medical Journal,38;129-133,1991

27)Detection of DNA damage induced by hexavalent chromium in vitro and in vivo.-Comparison of comet assay ,alkaline elution method and K-SDS precipitation method-
Ueno,S., Yamaguchi, M.,Fukushima,T.,Matsuda,T.,Susa,N.,Furukawa,Y.,Sugiyama,M.
Environ.Mutagen.Res.,21:219-223,1999

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